Saccharomyces Boulardii
Also known as: S. boulardii, Probiotic Yeast
A clinically studied probiotic yeast used for antibiotic-associated diarrhea, traveler's diarrhea, and gut resilience.
What it is
Saccharomyces boulardii is a beneficial probiotic yeast, not a bacterial probiotic. It is one of the most clinically studied probiotic organisms for antibiotic-associated diarrhea, traveler's diarrhea, and acute digestive disruption. Because it is a yeast, it is not killed by antibiotics, making it especially useful during or after antibiotic use.
How it works
S. boulardii supports gut barrier integrity, helps neutralize certain bacterial toxins, modulates immune signaling in the gut, and competes with pathogens for adhesion sites. It also supports secretory IgA and short-term microbiome resilience during digestive stress. Unlike many bacterial probiotics, it does not permanently colonize the gut; it acts transiently while being consumed.
Clinical dose range
5–10 billion CFU/day
Common clinical dosing is 5–10 billion CFU/day, often divided into 1–2 servings. For antibiotic-associated diarrhea prevention, it is typically taken during the antibiotic course and continued for several days afterward. Follow product-specific storage instructions.
Forms comparison
What to look for on the label
- Strain identified, ideally CNCM I-745 or equivalent
- CFU guaranteed through expiration, not only at manufacture
- Moisture-resistant packaging and clear storage instructions
- No vague 'proprietary probiotic blend' without strain-level detail
Health goals supported
Safety & dosing notes
Generally safe for healthy adults. Avoid in severely immunocompromised people, critically ill patients, or those with central venous catheters due to rare fungemia risk. Consult a clinician for persistent diarrhea, fever, or blood in stool.
SuppsBuddy gives strong scores to S. boulardii products that disclose strain and CFU at expiration. Generic probiotic blends that do not identify the organism at strain level receive lower evidence and transparency scores.
Frequently asked questions
What is Saccharomyces Boulardii?
Saccharomyces boulardii is a beneficial probiotic yeast, not a bacterial probiotic. It is one of the most clinically studied probiotic organisms for antibiotic-associated diarrhea, traveler's diarrhea, and acute digestive disruption. Because it is a yeast, it is not killed by antibiotics, making it especially useful during or after antibiotic use.
How does Saccharomyces Boulardii work?
S. boulardii supports gut barrier integrity, helps neutralize certain bacterial toxins, modulates immune signaling in the gut, and competes with pathogens for adhesion sites. It also supports secretory IgA and short-term microbiome resilience during digestive stress. Unlike many bacterial probiotics, it does not permanently colonize the gut; it acts transiently while being consumed.
What is the typical clinical dose range for Saccharomyces Boulardii?
5–10 billion CFU/day. Common clinical dosing is 5–10 billion CFU/day, often divided into 1–2 servings. For antibiotic-associated diarrhea prevention, it is typically taken during the antibiotic course and continued for several days afterward. Follow product-specific storage instructions.
What forms of Saccharomyces Boulardii should I look for?
S. boulardii CNCM I-745: Clinically studied strain used in many trials | S. boulardii with disclosed CFU at expiration: Ensures viable dose through shelf life | Generic probiotic blend hiding strain and CFU: Cannot verify strain identity or clinically relevant dose
Is Saccharomyces Boulardii safe?
Generally safe for healthy adults. Avoid in severely immunocompromised people, critically ill patients, or those with central venous catheters due to rare fungemia risk. Consult a clinician for persistent diarrhea, fever, or blood in stool. This information is educational and is not medical advice.
How does SuppsBuddy evaluate Saccharomyces Boulardii?
SuppsBuddy gives strong scores to S. boulardii products that disclose strain and CFU at expiration. Generic probiotic blends that do not identify the organism at strain level receive lower evidence and transparency scores.
Related ingredients
This page is for educational purposes only. These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any supplement.