Resveratrol
Also known as: Trans-Resveratrol, Pterostilbene
The red wine polyphenol with sirtuin-activating and anti-inflammatory properties — but requires trans form and meaningful dose.
What it is
Resveratrol is a naturally occurring polyphenol stilbene found in the skin of red grapes, blueberries, and Japanese knotweed (the primary commercial source). It gained global attention following the 'French Paradox' research and subsequent studies showing life extension in yeast, worms, flies, and mice. Human clinical evidence is more modest, but emerging trials in aging populations show promising metabolic and cardiovascular effects.
How it works
Resveratrol activates SIRT1 (Sirtuin 1) — a NAD+-dependent deacetylase that regulates metabolism, stress response, and inflammatory gene expression. It also inhibits mTOR (a nutrient-sensing pathway that when chronically activated accelerates aging), activates AMPK (the cellular energy sensor), and inhibits cyclooxygenase enzymes (anti-inflammatory). Bioavailability is a significant challenge — resveratrol is rapidly metabolized in the gut and liver.
Clinical dose range
250–1,000 mg/day trans-resveratrol
Only the trans-resveratrol isomer is biologically active. Cis-resveratrol (common in poorly stored or processed products) has minimal activity. Bioavailability is improved with food, particularly with fat-containing meals. Some research uses 1,000–2,000 mg/day for significant metabolic effects.
Forms comparison
What to look for on the label
- Specifies trans-resveratrol (not just 'resveratrol')
- Trans-resveratrol purity ≥98% from Japanese knotweed or synthetic source
- Third-party tested for trans vs. cis isomer ratio
- Stored in opaque, airtight packaging — resveratrol degrades in light and heat
Health goals supported
Safety & dosing notes
Generally safe at supplemental doses. High doses (>2,500 mg/day) may cause GI side effects. May have mild estrogenic activity at very high doses — theoretical concern in hormone-sensitive conditions. Inhibits CYP enzymes at high doses — potential drug interactions with medications metabolized by CYP1A2 and CYP3A4.
SuppsBuddy requires trans-resveratrol specification and penalizes products that do not disclose isomer purity. Given its emerging evidence tier, the analysis clearly communicates the difference between animal research and human trial outcomes.
Frequently asked questions
What is Resveratrol?
Resveratrol is a naturally occurring polyphenol stilbene found in the skin of red grapes, blueberries, and Japanese knotweed (the primary commercial source). It gained global attention following the 'French Paradox' research and subsequent studies showing life extension in yeast, worms, flies, and mice. Human clinical evidence is more modest, but emerging trials in aging populations show promising metabolic and cardiovascular effects.
How does Resveratrol work?
Resveratrol activates SIRT1 (Sirtuin 1) — a NAD+-dependent deacetylase that regulates metabolism, stress response, and inflammatory gene expression. It also inhibits mTOR (a nutrient-sensing pathway that when chronically activated accelerates aging), activates AMPK (the cellular energy sensor), and inhibits cyclooxygenase enzymes (anti-inflammatory). Bioavailability is a significant challenge — resveratrol is rapidly metabolized in the gut and liver.
What is the typical clinical dose range for Resveratrol?
250–1,000 mg/day trans-resveratrol. Only the trans-resveratrol isomer is biologically active. Cis-resveratrol (common in poorly stored or processed products) has minimal activity. Bioavailability is improved with food, particularly with fat-containing meals. Some research uses 1,000–2,000 mg/day for significant metabolic effects.
What forms of Resveratrol should I look for?
Trans-resveratrol (≥98% purity): The biologically active isomer; must be explicitly specified on label | Pterostilbene (methylated resveratrol analog): Better bioavailability than resveratrol; longer half-life; similar mechanisms | Resveratrol from Japanese knotweed extract: Natural source; trans-resveratrol content must be standardized and verified | Non-standardized red wine extract: Extremely low resveratrol content; not clinically meaningful
Is Resveratrol safe?
Generally safe at supplemental doses. High doses (>2,500 mg/day) may cause GI side effects. May have mild estrogenic activity at very high doses — theoretical concern in hormone-sensitive conditions. Inhibits CYP enzymes at high doses — potential drug interactions with medications metabolized by CYP1A2 and CYP3A4. This information is educational and is not medical advice.
How does SuppsBuddy evaluate Resveratrol?
SuppsBuddy requires trans-resveratrol specification and penalizes products that do not disclose isomer purity. Given its emerging evidence tier, the analysis clearly communicates the difference between animal research and human trial outcomes.
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This page is for educational purposes only. These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any supplement.