Phosphatidylserine

Phosphatidylserine (PS) is a phospholipid and the primary structural component of neuronal cell membranes, particularly in the inner leaflet where it regulates membrane fluidity and receptor function. It is found in high concentrations in the brain and is commercially derived from sunflower or soy lecithin (replacing bovine brain sources discontinued over BSE concerns). It is unique in being the only supplement with an FDA-qualified health claim (2003) for reducing the risk of dementia and cognitive dysfunction.

PS supports neuronal membrane integrity, influences receptor density (including those for dopamine, acetylcholine, and serotonin), and modulates apoptosis pathways. Its most consistent clinical finding is blunting the cortisol and ACTH response to exercise stress — making it particularly interesting for athletes and high-stress individuals. Memory and cognitive benefits are most pronounced in age-related cognitive decline, with more modest effects in healthy young adults.

100–400 mg/day. 100 mg three times daily (300 mg/day total) is the most studied dose for cognitive outcomes. For cortisol blunting in athletes, 400–800 mg/day before training has been studied. Take with food — PS is fat-soluble.

Sunflower-derived PS (Sharp-PS®): Non-soy, non-GMO; cleanest raw material; equivalent efficacy to soy-derived | Soy-derived PS: Original clinical research form; highly effective; non-GMO versions available | Bovine brain PS: Removed from market due to BSE risk; no longer commercially available

Excellent safety profile. Mild GI side effects possible at high doses. May have mild anticoagulant effects at very high doses — caution with blood thinners. No established UL. This information is educational and is not medical advice.

SuppsBuddy validates that products disclose PS content (not just total phospholipid) and checks the source (sunflower vs. soy). Sharp-PS® branded ingredient receives the highest form quality score.