Apigenin
Also known as: Chamomile Extract, Parsley Flavone, 4',5,7-Trihydroxyflavone
A calming flavonoid popular for sleep support, relaxation, and nighttime supplement stacks.
What it is
Apigenin is a naturally occurring flavonoid found in chamomile, parsley, celery, and other plants. It has become popular in sleep and longevity supplement stacks because of its calming profile and its presence in chamomile, one of the most widely used relaxation botanicals. Human research on isolated apigenin is still limited, so evidence is promising but not as mature as magnesium, melatonin, or glycine.
How it works
Apigenin appears to interact with GABA-A benzodiazepine receptor sites, which may contribute to relaxation and sleep support. It also has antioxidant and anti-inflammatory signaling effects in preclinical models. In practical supplement use, it is typically positioned as a gentle nighttime compound rather than a strong sedative.
Clinical dose range
25–50 mg/day
Common supplemental doses are 25–50 mg taken in the evening. Chamomile extracts may list apigenin content indirectly, so isolated apigenin dosing is easier to evaluate. Human dose-response data remains limited.
Forms comparison
What to look for on the label
- Apigenin dose clearly listed in mg
- If sourced from chamomile, apigenin standardization disclosed
- Third-party tested for purity and pesticide residues
- No proprietary sleep blend hiding the active amount
Health goals supported
Safety & dosing notes
May cause drowsiness and should be used cautiously with sedatives, alcohol, or sleep medications. People taking anticoagulants or medications metabolized by CYP enzymes should consult a clinician, as flavonoids may influence drug metabolism.
SuppsBuddy treats apigenin as an emerging sleep-support ingredient. Products with clear 25–50 mg dosing score better than chamomile blends that do not disclose standardized apigenin content.
Frequently asked questions
What is Apigenin?
Apigenin is a naturally occurring flavonoid found in chamomile, parsley, celery, and other plants. It has become popular in sleep and longevity supplement stacks because of its calming profile and its presence in chamomile, one of the most widely used relaxation botanicals. Human research on isolated apigenin is still limited, so evidence is promising but not as mature as magnesium, melatonin, or glycine.
How does Apigenin work?
Apigenin appears to interact with GABA-A benzodiazepine receptor sites, which may contribute to relaxation and sleep support. It also has antioxidant and anti-inflammatory signaling effects in preclinical models. In practical supplement use, it is typically positioned as a gentle nighttime compound rather than a strong sedative.
What is the typical clinical dose range for Apigenin?
25–50 mg/day. Common supplemental doses are 25–50 mg taken in the evening. Chamomile extracts may list apigenin content indirectly, so isolated apigenin dosing is easier to evaluate. Human dose-response data remains limited.
What forms of Apigenin should I look for?
Isolated Apigenin: Allows precise 25–50 mg dosing and clear label evaluation | Standardized Chamomile Extract: Traditional source, but apigenin content must be disclosed for accurate scoring | Non-standardized calming blend: Cannot verify apigenin amount or clinical relevance
Is Apigenin safe?
May cause drowsiness and should be used cautiously with sedatives, alcohol, or sleep medications. People taking anticoagulants or medications metabolized by CYP enzymes should consult a clinician, as flavonoids may influence drug metabolism. This information is educational and is not medical advice.
How does SuppsBuddy evaluate Apigenin?
SuppsBuddy treats apigenin as an emerging sleep-support ingredient. Products with clear 25–50 mg dosing score better than chamomile blends that do not disclose standardized apigenin content.
Related ingredients
This page is for educational purposes only. These statements have not been evaluated by the FDA. This information is not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare professional before starting any supplement.